See below the best online sportsbooks available across the United States.
Buffalo Bills vs Tampa Bay Buccaneers - 12/12 4:25 pm ET
One of the most frustrating teams in the entire division are the Bills, who while clearly talented just haven't been able to find consistency in their game this season.
Their offense has struggled so far in games and now they take on the Buccaneers in a game they must win to have a hope of making the playoffs.
Tampa Bay, on the other hand, have finally found their form and with their offense starting to get healthy again it has allowed for Tom Brady to push forward and have yet another MVP-worthy season so far.
The Bills are desperate to claim victory, but after a short week and with Brady in great form it seems to set up for the Buccaneers to deal with them and earn the win.
Back the Bucks on spread!
Considering the form of the sides and the quality they both have, it's relatively surprising that the spread is only 3.5 in the Buccaneers' favor.
Buffalo have struggled against better opposition this season, losing to the likes of the Steelers, Titans, Colts and Patriots.
With Brady at the head of the offense, Tampa Bay have got a stacked attack and are more than capable of scoring well into the 30 point mark. Tre'Davious White will be missing from the Bills side with a torn ACL, which just further weighs things in Tampa's favor.
With their defensive weaknesses and the power in the Buccaneers' offense, I expect them to win this game by at least a touchdown but probably more.
Learn more about how to bet on the Tampa Bay Buccaneers here.
San Francisco 49ers vs Cincinnati Bengals - 12/12 4:25 pm ET
After defeats for both of these teams in Week 13, they both now need a victory against each other in order to be in with a chance of the wild card spot.
The 49ers have one of the best pass rushes in the whole NFL, which means this could be a long day at the office for the Bengals and their offensive setup. It's likely to be relatively even in the early exchanges but as the game goes on, don't be surprised if the 49ers take over and claim a much-needed triumph.
49ers to cover the spread
No Deebo Samuel could be a problem for the 49ers, who just aren't quite the same without him. A groin problem will see him sit this one out but even with his absence, I expect San Francisco to have enough to get over the line.
Neither side will dominate and there won't be a blowout regardless of the teams that are out on the field, but with a positive spread and the better offense between the two sides, the easy bet here is for the 49ers to cover the spread and secure a victory.